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GSTM1 and GSTT1 genotypes on bladder cancer risk

Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk To evaluate the association between genetic polymorphism of GSTM1, GSTT1 and development of bladder cancer, a hospital-based case-control study was conducted in South Korea. The study population consisted of 232 histologically confirmed male bladder cancer cases and 165 male controls enrolled from urology departments with no previous history of cancer or systemic diseases in Seoul during 1997-1999. The GSTM1 null genotype was significantly associated with bladder cancer (OR: 1.6, 95% CI: 1.0-2.4), whereas the association observed for GSTT1 null genotype did not reach statistical significance (OR: 1.3, 95%

Occupational exposure limits for heat stress in outdoor workers

MMWR (Morbidity and Mortality Weekly Report) of Centers for Disease Control and Prevention (CDC) have posted "Evaluation of Occupational Exposure Limits for Heat Stress in Outdoor Workers — United States, 2011–2016." Even though National Institute for Occupational Safety and Health (NIOSH) and American Conference of Governmental Industrial Hygienists (ACGIH) published occupational exposure limit for heat stress, these limits were derived from experimental condition, not real life outdoor environment. So, To evaluate outdoor heat exposure threshold, CDC reviewed 25 outdoor occupational heal-related illness, and concluded: "A Heat Index of 85°F (29.4°C) could be used as a screening threshold t

 

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