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[Updated] The medical article published in the name of OHRC


The article "Higher and increased concentration of hs-CRP within normal range can predict the incidence of metabolic syndrome in healthy men" will be published in Nov 2018, The first author of the article is the president of OHRC(Occupation and Health Research Center) and this article will be the first published article under OHRC.

* Update: The publication of this article was confirmed as follow.

Volume 12, Issue 6, November 2018, Pages 977-983

Diabetes & Metabolic Syndrome: Clinical Research & Reviews. (ESCI journal)

The detailed information about this article is below.

Title: Higher and increased concentration of hs-CRP within normal range can predict the incidence of metabolic syndrome in healthy men

Aims: To determine whether hs-CRP level and interval change of hs-CRP could predict the development of metabolic abnormalities in healthy subjects in a longitudinal study.

Methods: A cohort of 3748 male who had normal hs-CRP level without evidence of any component of metabolic syndrome were studied. At each visit, hs-CRP level and metabolic abnormalities were measured. Interval change of hs-CRP for each subject was calculated. COX proportional hazard model and logistic regression analysis were used.

Results: Cumulative incidence and incidence density of metabolic syndrome were 3.96% and 7.17 per 1000 person-year, respectively. Cumulative incidence of metabolic syndrome was significantly increased according to hs-CRP tertile level. This significance remained after adjusting age, smoking, drinking, and exercise. Although the hazard ratio of metabolic syndrome for incidence density was increased significantly as hs-CRP increased, such trend disappeared after adjusting for confounding variables. The risk of metabolic syndrome was significantly higher (1.48 times) in the hs-CRP increased group than that in the decreased or unchanged group. This significance remained after controlling for covariates.

Conclusion: Relatively higher hs-CRP level within normal range may predict the increase of metabolic syndrome compared to lower hs-CRP. Increased hs-CRP level may increase the incidence of metabolic syndrome.

Publication:

Volume 12, Issue 6, November 2018, Pages 977-983

Diabetes & Metabolic Syndrome: Clinical Research & Reviews. (ESCI journal)

Link 1: this article @ PubMed

Link 2: this article @ ScienceDirect

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